Cadherin 17 (CDH17), also known as liver–intestinal cadherin (LI-cadherin), is a transmembrane glycoprotein involved in cell adhesion. It is expressed in normal intestinal epithelium (colon including appendix and small intestine), pancreatic excretory ducts, and occasionally in gallbladder epithelium and intrahepatic bile ducts. CDH17 is not expressed in liver hepatocytes, nor is it expressed in other normal tissues including lung, breast, kidney, stomach, placenta, thymus, adrenal gland, prostate, skeletal muscle, heart, cerebrum, cerebellum, testis or salivary gland.
Intended use
CDH17 has proven useful in identifying carcinomas of colorectal, gastric, and pancreatic origin. It is detected in 96-100% of colorectal carcinomas, 43-90% of gastric carcinomas, and 39-82% of pancreatic ductal carcinomas.
Compared with other commonly used markers such as CDX2 and CK20, CDH17 shows superior sensitivity in detecting colorectal, gastric, and pancreatic carcinomas.
CDH17 expression has also been reported in neuroendocrine neoplasms, with increased immunoreactivity from the upper to lower gastrointestinal tract. Its selective expression pattern makes it a valuable diagnostic marker for distinguishing gastrointestinal malignancies from other tumour types.
References:
Su MC, Yuan RH, Lin CY, Jeng YM. Cadherin-17 is a useful diagnostic marker for adenocarcinomas of the digestive system. Mod Pathol. 2008; 21(11): 1379-86. https://doi.org/10.1038/modpathol.2008.107.
Jacobsen F, Pushpadevan R, Viehweger F, Freytag M, Schlichter R, Gorbokon N, Büscheck F, Luebke AM, Putri D, Kluth M, Hube-Magg C, Hinsch A, Höflmayer D, Fraune C, Bernreuther C, Lebok P, Sauter G, Minner S, Steurer S, Simon R, Burandt E, Dum D, Lutz F, Marx AH, Krech T, Clauditz TS. Cadherin-17 (CDH17) expression in human cancer: A tissue microarray study on 18,131 tumors. Pathol Res Pract. 2024; 256: 155175. https://doi.org/10.1016/j.prp.2024.155175.
Altree-Tacha D, Tyrrell J, Haas T. CDH17 Is a More Sensitive Marker for Gastric Adenocarcinoma Than CK20 and CDX2. Arch Pathol Lab Med. 2017; 141(1): 144-150. https://doi.org/10.5858/arpa.2015-0404-OA.
Panarelli NC, Yantiss RK, Yeh MM, Liu Y, Chen YT. Tissuespecific cadherin CDH17 is a useful marker of gastrointestinal adenocarcinomas with higher sensitivity than CDX2. Am J Clin Pathol. 2012; 138(2): 211-22. https://doi.org/10.1309/ajcpkshxi3xehw1j.
Takamura M, Sakamoto M, Ino Y, Shimamura T, Ichida T, Asakura H, Hirohashi S. Expression of liver-intestine cadherin and its possible interaction with galectin-3 in ductal adenocarcinoma of the pancreas. Cancer Sci. 2003; 94(5): 425-30. https://doi.org/10.1111/j.1349-7006.2003.tb01459.x.
EMSCA0001EN